There were mistakes in defence for sure, but our midfield situation allowed them to apply constant and direct pressure on our defence with world class attackers, it's disappointing but not a surprise mistakes were made / taken advantage of. Hendersons a decent stand in at DM, but we're playing away at one of the best sides in Europe, they're going to expose him, especially when his midfield cover on the right hand side is Naby whose defensive game isn't great, and on the left is Milner, who's clearly shattered from weeks of back to back games.
Also on that right hand side, and this isn't a criticism as I think he was instructed to play this way, but it seemed Salah wasn't working as hard to track back as usual, maybe because Klopp wanted him high as to pin back Carrasco, but it did give them much more licence on the right hand side with Joao Felix and Lemar, which is where they hurt us.
Despite all this, they required two moments of shocking defending by Naby, and one moment on confusion by VVD to get their goals, and then there's the fact that the first goal should never have stood, the rules and the rules I suppose, so maybe we can curse the fact we've falling into a grey area of the rule book, but without Lemar in an offside position distracting Matip, both but running past him from behind, and from being in the path of the ball, Matip clears that.
For those reasons I'm not too concerned about the defence, but it's still completely fair to say that mentally not quite at the same level as two years ago, but in all fairness, that was one of the best defences world football has ever seen.